Biochemists and biologists at the University of Innsbruck, Austria, have retraced the function of an important human cancer gene 600 million years back in time.
For the first time, they have identified the oncogene 'myc' in a freshwater microorganism and have shown that this oncogene has similar biochemical functions in ancestral metazoan and in humans. The scientists published their findings in PNAS.
The myc gene plays an important role in the growth of organisms. It produces a protein that acts as a gene regulator, which controls the expression of up to 15 % of all human genes. This means that it controls whether these genes are activated or deactivated.
A deregulation of the myc gene leads to uncontrolled cell proliferation and to cancer; a deregulated myc gene occurs in about 30% of all human cancers.
“To get a better understanding of the deregulation process caused by the oncogene, we would have to know which genes are regulated by myc and which of these are important for cancers“, says Klaus Bister from the Institute of Biochemistry at the University of Innsbruck.
Due to the complexity of the human organism, researchers use simpler model systems for their experiments, whose results may then be translated to humans. The Innsbruck scientific teams of Klaus Bister, Markus Hartl and Bert Hobmayer have, for the first time, identified the oncogene in a fresh water polyp (Hydra) and they have shown that it has very similar functions when compared with humans.
